O'Sheas on Princess Street in central Manchester was also shortlisted for the Best Cocktail Experience and the Best Food Experience at the Irish Pubs Global awards.
The city centre pub - which celebrates its 25th anniversary next year - is operated by Dominic Winters and Paul Mackey, and is part of Heineken's Star pubs leased estate.
The publicans introduced food to O'Sheas about 18 months ago and appointed Stephen Baird as head chef to deliver the new offer.
The menu includes traditional Irish favourites such as its best-selling Full Irish Fry – or Breakfast - which comes with Conakilty sausage, black and white pudding and homemade soda bread.
Colcannon mash – made with onions and cabbage – is another traditional Irish dish proving popular.
O'Sheas' drinks selection has an equally Irish flavour and a range of Irish whiskeys and gins forms the basis of the pub's cocktail menu.
The judging process involved nominations by members of the public, with final decisions being made by an international panel of 16 judges. The team from O'Sheas received their award at a ceremony at The Galmont Hotel in Galway.
Paul said about winning the award: "It's the icing on the cake after a great 18 months since we opened the new look O'Sheas and launched our food offering.
"It's much appreciated recognition for all the hard work of Stephen, his kitchen team and the front of house staff and puts O'Sheas on the map of the bustling food and drink scene in Manchester."
David Pritchard, Star Pubs & Bars operations director for the North West, said: "This award is well deserved. Paul and Dominic are superb operators and have created an authentic Irish offer that has stood the test of time."
O'Sheas opened in Manchester in 1994 and has served over 2,000,000 pints of Guinness since then.
The building was built in 1905 as a packing and shipping warehouse in the middle of a predominantly Irish area between Little Ireland and St Austins.